Roadmap Epigenomics Project

Program Initiatives

Reference Epigenome Mapping Centers

This initiative is being issued as a cooperative agreement (U01) to support reference epigenome production centers that will develop reference epigenomes of a variety of human cells.

Epigenomics Data Analysis and Coordination Center (EDAAC)

This cooperative agreement (U01) will fund the Epigenomics Data Analysis and Coordination Center (EDACC), which will provide data analysis and coordination for all of the Reference Epigenome Mapping Centers.

Technology Development in Epigenomics

This initiative will support technology development in two important areas of epigenetics research.

Discovery of Novel Epigenetic Marks in Mammalian Cells

This initiative will support research to identify stable, long term changes in epigenetic processes and establish the utility of these marks in mammalian cells. More Epigenomics of Human Health and Disease

Epigenomics of Human Health and Disease

This initiative will support research on fundamental epigenomic changes or mechanisms underlying specific diseases; conditions of development or aging; or response to exposures (physical, chemical, behavioral, and social factors).

Reference Epigenome Mapping Centers

This initiative is being issued as a cooperative agreement (U01) to support reference epigenome production centers that will develop reference epigenomes of a variety of human cells. The cell types will be selected by the network of awardees with advice from an international committee, but are likely to include human embryonic stem cells, differentiating cells, selected differentiated cell lines representative of human disease, and select human primary cells that are relevant to complex human disease. These reference epigenomes will serve as a resource and be utilized by the scientific community to identify potential therapeutic targets, enhance understanding of disease mechanisms, provide additional insights to genetic susceptibility of disease, pursue therapeutic opportunities in stem cell based and tissue regeneration strategies, and to understand normal differentiation, development, and aging/senescence. This RFA is due to release in Fall 2007, with funding expected to begin in Fall 2008.